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dc.creatorJimenez, Maria K.en_US
dc.creatorFradkin, Leoniden_US
dc.creatorNieman, Linda T.en_US
dc.creatorLam, Sylviaen_US
dc.creatorPoh, Catherineen_US
dc.creatorSokolov, Konstantinen_US
dc.date.accessioned2016-10-28T19:53:10Z
dc.date.available2016-10-28T19:53:10Z
dc.date.issued2013-02en_US
dc.identifierdoi:10.15781/T24746V0X
dc.identifier.citationJimenez, Maria K., Leonid Fradkin, Linda T. Nieman, Sylvia Lam, Catherine Poh, and Konstantin Sokolov. "Oblique polarized reflectance spectroscopy for depth sensitive measurements in the epithelial tissue." In SPIE BiOS, pp. 859203-859203. International Society for Optics and Photonics, (Feb., 2013)en_US
dc.identifier.issn0277-786Xen_US
dc.identifier.urihttp://hdl.handle.net/2152/43330
dc.description.abstractOptical spectroscopy has shown potential as a tool for precancer detection by discriminating alterations in the optical properties within epithelial tissues. Identifying depth-dependent alterations associated with the progression of epithelial cancerous lesions can be especially challenging in the oral cavity due to the variable thickness of the epithelium and the presence of keratinization. Optical spectroscopy of epithelial tissue with improved depth resolution would greatly assist in the isolation of optical properties associated with cancer progression. Here, we report a fiber optic probe for oblique polarized reflectance spectroscopy (OPRS) that is capable of depth sensitive detection by combining the following three approaches: multiple beveled fibers, oblique collection geometry, and polarization gating. We analyze how probe design parameters are related to improvements in collection efficiency of scattered photons from superficial tissue layers and to increased depth discrimination within epithelium. We have demonstrated that obliquely-oriented collection fibers increase both depth selectivity and collection efficiency of scattering signal. Currently, we evaluate this technology in a clinical trial of patients presenting lesions suspicious for dysplasia or carcinoma in the oral cavity. We use depth sensitive spectroscopic data to develop automated algorithms for analysis of morphological and architectural changes in the context of the multilayer oral epithelial tissue. Our initial results show that OPRS has the potential to improve the detection and monitoring of epithelial precancers in the oral cavity.en_US
dc.description.sponsorshipen_US
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.subjectfluorescence spectroscopy; optical spectroscopy; fiberoptic probe; in-vivo; scattering spectroscopy; light-scattering; turbid media; phantoms; design; modelen_US
dc.titleOblique Polarized Reflectance Spectroscopy for Depth Sensitive Measurements in the Epithelial Tissueen_US
dc.typeProceedings Paperen_US
dc.description.departmentBiomedical Engineeringen_US
dc.rights.restrictionOpenen_US
dc.identifier.doi10.1117/12.2004875en_US
dc.contributor.utaustinauthorJimenez, Maria K.en_US
dc.contributor.utaustinauthorFradkin, Leoniden_US
dc.contributor.utaustinauthorSokolov, Konstantinen_US
dc.relation.ispartofserialBiomedical Applications of Light Scattering VIIen_US


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