Show simple item record

dc.creatorBrager, Darrin H.en_US
dc.creatorAkhavan, Arvin R.en_US
dc.creatorJohnston, Danielen_US
dc.date.accessioned2016-10-28T19:51:17Z
dc.date.available2016-10-28T19:51:17Z
dc.date.issued2012-03en_US
dc.identifierdoi:10.15781/T28G8FM1B
dc.identifier.citationBrager, Darrin H., Arvin R. Akhavan, and Daniel Johnston. "Impaired dendritic expression and plasticity of h-channels in the fmr1?/y mouse model of fragile X syndrome." Cell reports, Vol. 1, No. 3 (Mar., 2012): 225-233.en_US
dc.identifier.issn2211-1247en_US
dc.identifier.urihttp://hdl.handle.net/2152/43236
dc.description.abstractDespite extensive research into both synaptic and morphological changes, surprisingly little is known about dendritic function in fragile X syndrome (FXS). We found that the dendritic input resistance of CA1 neurons was significantly lower in fmr1(-/y) versus wild-type mice. Consistent with elevated dendritic I-h, voltage sag, rebound, and resonance frequency were significantly higher and temporal summation was lower in the dendrites of fmr1(-/y) mice. Dendritic expression of the h-channel subunit HCN1, but not HCN2, was higher in the CA1 region of fmr1(-/y) mice. Interestingly, whereas mGluR-mediated persistent decreases in Ih occurred in both wildtype and fmr1(-/y) mice, persistent increases in Ih that occurred after LTP induction in wild-type mice were absent in fmr1(-/y) mice. Thus, chronic upregulation of dendritic Ih in conjunction with impairment of homeostatic h-channel plasticity represents a dendritic channelopathy in this model of mental retardation and may provide a mechanism for the cognitive impairment associated with FXS.en_US
dc.description.sponsorshipFRAXAen_US
dc.description.sponsorshipUniversity of Texas Austin Undergraduate Research Fellowshipen_US
dc.description.sponsorshipNational Institutes of Health Grant MH048432en_US
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.subjectmental-retardation proteinen_US
dc.subjectca1 pyramidal neuronsen_US
dc.subjectraten_US
dc.subjecthippocampal-neuronsen_US
dc.subjecttemporal-lobe epilepsyen_US
dc.subjectlong-term potentiationen_US
dc.subjecti-hen_US
dc.subjectmessenger-rnasen_US
dc.subjectexcitabilityen_US
dc.subjecttranslationen_US
dc.subjectmodulationen_US
dc.subjectcell biologyen_US
dc.titleImpaired Dendritic Expression and Plasticity Of H-Channels in the fmr1(-/Y) Mouse Model of Fragile X Syndromeen_US
dc.typeArticleen_US
dc.description.departmentCenter for Learning and Memoryen_US
dc.rights.restrictionOpenen_US
dc.identifier.doi10.1016/j.celrep.2012.02.002en_US
dc.contributor.utaustinauthorBrager, Darrin H.en_US
dc.contributor.utaustinauthorAkhavan, Arvin R.en_US
dc.contributor.utaustinauthorJohnston, Danielen_US
dc.relation.ispartofserialCell Reportsen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record