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Studies toward the total synthesis of (–)-stolonidiol : a small molecule inducer of choline acetyltransferase
(2012-05)
The marine diterpene (–)-stolonidiol (1) has been shown to upregulate neuronal levels of acetylcholine. The mechanism through which a small molecule can impart this allosteric-like effect is currently unknown. A laboratory ...
Synthetic studies on the pluramycin family of antitumor antibiotics : the total synthesis of isokidamycin
(2010-12)
A total synthesis of the complex C-aryl glycoside isokidamycin was achieved during an effort to construct the natural product kidamycin, a member of the pluramycin family of antitumor antibiotics. The angolosamine ...
Formation of C-C bonds via transfer hydrogenation : from methodology development to natural product synthesis
(2013-08)
Under the conditions of transfer hydrogenation employing ortho-cyclometallated iridium C,O-benzoate catalysts, selective silylallylation and CF₃-allylation were developed. In both cases, high levels of catalyst-directed ...
An approach towards the synthesis of Nakadomarin A and Manzamine A Using Pauson-Khand technology
(2004-05)
This dissertation is devoted to our synthetic studies towards the total synthesis of the natural product Nakadomarin A, and Manzamine A using the Pauson-Khand reaction as the key step. Chapter 1 reviews past work using ...
Development of multicomponent assembly processes and their application to the synthesis of novel heterocyclic scaffolds and the total synthesis of actinophyllic acid : application of an iminium ion mediated cascade
(2013-08)
Several novel multicomponent assembly processes have been developed for the preparation of a diverse array of complex heterocyclic systems from relatively simple starting materials. These studies resulted in the discovery ...
Carbon-carbon bond formation via catalytic hydrogenation and transfer hydrogenation : application in the total synthesis of bryostatin 7
(2012-08)
Under the conditions of transfer hydrogenation employing ortho-cyclometallated iridium C,O-benzoate catalysts, two protocols of iterative chain elongation of 1,3-diols to furnish 1,3-polyols were developed. First, ...
Application of the Moore rearrangement to the synthesis of 1,4-dioxygenated xanthones and efforts toward the total synthesis of lundurine B
(2012-12)
A novel application of the Moore rearrangement was successfully developed and applied to the synthesis of 1,4-dioxygenated xanthones that would have been difficult to obtain otherwise. The 1,4-dioxygenated xanthone moiety ...
Development and application of metal catalyzed transfer hydrogenative C-C bond forming reactions
(2016-05)
While polyketides display a diverse range of biological properties and are used extensively in human medicine, a lack of methods for the concise preparation of these complex structures still poses a significant challenge ...
Synthetic studies towards the total synthesis of cortistatin A synthesis of the pentacyclic core of citreamicin µ and GA-ring model studies
(2016-08)
The route to the key bicyclic intermediate was streamlined to eight steps in 16% yield, using a TMSI promoted coupling of a furan and an enone. Additionally, methodology for the selective ozonolysis of the bicyclic ...
Total syntheses of the neuroregenerative natural products vinaxanthone and xanthofulvin and biosynthetic studies
(2012-12)
Total syntheses of the neuroregenerative natural products vinaxanthone and xanthofulvin have been accomplished. The synthetic routes to both molecules utilize a highly regioselective furan Diels-Alder cycloaddition - ...