Search
Now showing items 1-10 of 23
Development of photodissociation methods for biomolecule analysis in a quadupole ion trap mass spectrometer
(2008-05)
Photodissociation methods have been implemented and compared to collision-induced dissociation (CID) in a quadrupole ion trap mass spectrometer for the structural analysis of peptides, proteins, oligosaccharides, DNA and ...
De novo sequencing and peptide characterization via ultraviolet photodissociation mass spectrometry
(2015-05)
Although in silico database search methods remain more popular for shotgun proteomics methods, de novo sequencing offers the ability to identify proteins lacking sequenced genomes and ones with subtle splice variants or ...
Studies of complexation and properties of metal ion guests with macrocyclic hosts using electrospray ionization quadrupole ion trap mass spectrometry
(2003)
This research is focused on the detection and analysis of host-guest chemistry involving primarily hosts that are novel organic compounds or cyclic peptides and guests that are metal ions. Detection and analysis are by ...
Advancement of photodissociation and electron-based tandem mass spectrometry methods for proteome analysis
(2011-08)
The number and types of diagnostic ions obtained by infrared multiphoton dissociation (IRMPD) and collision induced dissociation (CID) were evaluated for supercharged peptide ions created by electrospray ionization of ...
Biopolymer analysis by electrospray ionization and tandem mass spectrometry
(2004)
Electrospray ionization was used in conjunction with Fourier-transform ion cyclotron resonance (FTICR) mass spectrometry and quadrupole ion trap (QIT) mass spectrometry to study protein and oligonucleotide ions in vacuo. ...
Advanced development of ambient ionization mass spectrometry imaging methods and their utilization towards the understanding of metabolic diseases
(2020-07-06)
Ambient ionization mass spectrometry (MS) technologies offer a unique opportunity to bring the specificity and sensitivity of MS into clinics, potentially allowing rapid analyses of biospecimens without need for sample ...
Molecular characterization of biological samples by ambient ionization mass spectrometry to advance clinical assessment of human disease
(2021-06-16)
Ambient ionization mass spectrometry (MS) approaches have revolutionized the way diagnostic molecular information can be obtained from biological and clinical samples, requiring minimal to no sample pretreatment, being ...
Development of tandem mass spectrometric methods for proteome analysis utilizing photodissociation and ion/ion reactions
(2013-08)
The utility of 193 nm ultraviolet photodissociation (UVPD) and negative electron transfer dissociation (NETD) for the characterization of peptide anions was systematically evaluated. UVPD outperformed NETD in nearly all ...
Development of ultraviolet photodissociation based tandem mass spectrometry methods for the characterization of protein macromolecular structures and glycolipids
(2014-05)
Photon-based tandem mass spectrometry provides a versatile ion activation strategy for the analysis of polypeptides, proteins, and lipids. 351-nm ultraviolet photodissociation mass spectrometry (UVPD-MS) is a facile and ...
Investigation of tertiary structure of electrosprayed ribosomal protein L9 by Fourier transform ion cyclotron resonance mass spectrometry using low energy dissociation techniques
(2003)
Tandem mass spectrometry, using infrared multi-photon dissociation
(IRMPD), sustained off-resonance irradiation (SORI), and complementary pair
analysis has been applied to small proteins in the 3 kDa range. In this ...