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Transition metal catalyzed carbonyl additions under the conditions of transfer hydrogenation
(2011-05)
The efficient construction of complex organic molecules mandates that an assortment of methods for forming C-C bonds be available to the practicing synthetic chemist. The addition of carbon based nucleophiles to carbonyl ...
Differential sensing of kinases.
(2014-05)
During the last decade, organic and supramolecular chemistry in combination with analytical and fluorescent-based sensing methods have led to the development of chemical biology tools to study protein phosphorylation in ...
Catalysis and materials development for photolithography
(2014-08)
In recent years the microelectronics industry as found itself at an impasse. The tradition pathway towards smaller transistors at lower costs has hit a roadblock with the failure of 157 nm lithography and the continued ...
Design and application of N,Nʹ-diamidocarbenes: expanding the constraints of stable carbene chemistry.
(2014-05)
Strategic incorporation of carbonyl groups into an N-heterocyclic carbene (NHC) scaffold via rapid and high-yielding methodologies culminating in classical deprotonation methods or the novel reduction of geminal dichlorides ...
Exploration of novel architectures for aromatic electronic donor-acceptor hetero-duplexes
(2011-12)
Research within the Iverson group has been primarily focused around the investigation of aromatic donor-acceptor interactions between an electron-rich 1,5-dialkoyxnaphthalene (DAN) molecule and the electron-deficient ...
Enantioselective synthesis of 2,2,5-Tri- and 2,2,5,5-tetrasubstituted tetrahydrofurans and synthesis of diketopiperazine containing natural products
(2012-12)
A chiral vinyl sulfoxide has been developed that undergoes highly diastereoselective Diels−Alder cycloadditions with various substituted furans in excellent yield. The cycloadducts can be stereoselectively transformed into ...
Sensing approaches for the discrimination of small molecules and multivalent analytes
(2014-12)
Differential arrays, composed of receptors that are capable of generating unique patterns of responses, have been shown to be useful for discrimination of molecular analytes. Herein, differential arrays have been developed ...
Sensing chiral amines via supramolecular chemistry and circular dichroism spectrometry
(2011-08)
In chapter 1 the principles behind circular dichroism spectroscopy and exciton coupled circular dichroism spectroscopy are outlined, and examples are cited that illustrate the utility of these methods in the determination ...
Studies in anion-responsive polymers and 6-shogaol as a chemopreventive of prostate cancer
(2014-08)
The study of the binding and recognition of anions has emerged as a significant branch of supramolecular chemistry over the past 20 years. Of particular interest is the binding in aqueous media of industrially or biologically ...