Now showing items 1-10 of 98
Investigation of micro- and nanoscale hydrogels as protein receptors for use in diagnostic biosensors
Due to the high cost and environmental instability of antibodies, there is precedent for developing synthetic molecular recognition agents for use in diagnostic sensors. Molecular imprinting was first investigated as a ...
Detection of microRNA by electrocatalytically amplified nanoparticle collisions
We report a new and general approach that will be useful for adapting the method of electrocatalytic amplification (ECA) to biosensing applications. In ECA, individual collisions of catalytic nanoparticles with a noncatalytic ...
Nanoparticles formed by anti-solvent precipitation to produce redispersible and amorphous drug powders
Anti-solvent precipitation produced sub-100 nm [Greek small letter beta]-carotene (BCN) particles despite only modest mixing energy. The particles were stabilized with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) ...
Improved oral bioavailability of poorly water soluble drugs using rapid freezing processes
A growing number of therapeutic compounds currently being developed by pharmaceutical companies are poorly water soluble leading to limited and/or erratic bioavailability. The rate limiting step for absorption of these ...
An evaluation of the use of superparamagnetic iron oxide nanoparticles to overcome extracellular barriers to lung disease for drug delivery
Primary barriers to drug delivery include mucus and biofilms, which can hinder drug and gene delivery by several orders of magnitude, preventing effective therapeutic effects. By understanding the physical and chemical ...
Nanostructured Ag produced by LAMA
Engineering nanocomposite polymer membranes for olefin/paraffin separation
In this dissertation, I have investigated applying the laser ablation of microparticle aerosol (LAMA) process to the production of nanocomposite polymer membranes for olefin/paraffin separation. Experimental results for ...
Detection of magneto-activated water/oil interfaces containing nanoparticles
Accurate, non-invasive determination of multiphase fluids distribution in reservoir rock can greatly help the evaluation and monitoring of oil reservoirs. This laboratory thesis research, carried but utilizing the biomedical ...
An electrostatic approach for producing nanoparticulate membranes using laser ablation of microparticle aerosols
The Laser Ablation of Microparticle Aerosols (LAMA) process produces nanoparticles by ablating microparticles that are entrained in an aerosol. Two of the main advantages of this process are that the particles produced ...