Abstract: Functionalization of the ubiquitous bis(imino)acenaphthene ligand class has been explored. The successful functionalization of this ligand type was found to be dependent upon the steric congestion encompassing ...

A combined experimental and theoretical approach is reported with a goal to develop a deeper understanding of strong metal support interactions (SMSI) and particularly their role in the oxygen reduction reaction (ORR). ...

Graphite oxide (GO), a carbon material prepared in one step from low cost commercial materials, and graphene oxide have been found to catalyze a wide range of reactions including oxidations, hydrations, and dehydrations, ...

The development of microdevices for applications related to bioanalysis is described. There are two types of microdevices involved in this study: DNA (or RNA) microarrays and bead-based microfluidic devices. First, a new ...

During the last decade, organic and supramolecular chemistry in combination with analytical and fluorescent-based sensing methods have led to the development of chemical biology tools to study protein phosphorylation in ...

Two enzyme model systems were employed to address fundamental questions regarding enzyme engineering via directed evolution. First, it was demonstrated that highly active glutathione transferases (GST) can be isolated ...

Diverse biological activities of polyketide natural products are often associated with specific structural motifs, biosynthetically introduced after construction of the polyketide core. Therefore, investigation of such ...

This dissertation is devoted to our synthetic studies towards the total synthesis of the natural product Nakadomarin A, and Manzamine A using the Pauson-Khand reaction as the key step. Chapter 1 reviews past work using ...

Anion Binding has recently emerged as an important field of study due to the role these small inorganic species play in a plethora of biological processes. Chapter 1 of this thesis describes the biological relevance and ...

Supramolecular chemists can be thought of as architects, who combine individual non-covalently bonded molecular building blocks, designed to be held together by intermolecular forces to create functional architectures. ...