The focus of this doctoral thesis is on the development of a chip-based sensor array, composed of individually addressable agarose micro-beads, that is suitable for the real-time detection of DNA oligonucleotides. This ...

Two methodologies, aimed at increasing the sensitivity and resolution of near-field scanning optical microscopy (NSOM), were explored. The NSOM motifs employed in this study involve the generation of highly localized ...

Heterocyclic alcohols were coupled with [pi]-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate to provide a variety of substituted [beta]-heteroaryl propionates, including those with contiguous ...

Abstract: Functionalization of the ubiquitous bis(imino)acenaphthene ligand class has been explored. The successful functionalization of this ligand type was found to be dependent upon the steric congestion encompassing ...

A combined experimental and theoretical approach is reported with a goal to develop a deeper understanding of strong metal support interactions (SMSI) and particularly their role in the oxygen reduction reaction (ORR). ...

Block copolymer self-assembly has demonstrated sub-optical lithographic resolution . High values of chi, the block copolymer interaction parameter, are required to achieve next-generation lithographic resolution . ...

Graphite oxide (GO), a carbon material prepared in one step from low cost commercial materials, and graphene oxide have been found to catalyze a wide range of reactions including oxidations, hydrations, and dehydrations, ...

The development of microdevices for applications related to bioanalysis is described. There are two types of microdevices involved in this study: DNA (or RNA) microarrays and bead-based microfluidic devices. First, a new ...

During the last decade, organic and supramolecular chemistry in combination with analytical and fluorescent-based sensing methods have led to the development of chemical biology tools to study protein phosphorylation in ...

Two enzyme model systems were employed to address fundamental questions regarding enzyme engineering via directed evolution. First, it was demonstrated that highly active glutathione transferases (GST) can be isolated ...