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The development of a microbead array for the detection and amplification of nucleic acids
(2006)
The focus of this doctoral thesis is on the development of a chip-based
sensor array, composed of individually addressable agarose micro-beads, that is
suitable for the real-time detection of DNA oligonucleotides. This ...
Enhanced electric fields at pointed metal probes for high resolution near-field imaging
(2007-05)
Two methodologies, aimed at increasing the sensitivity and resolution of near-field scanning optical microscopy (NSOM), were explored. The NSOM motifs employed in this study involve the generation of highly localized ...
Synthesis of [beta]-heteroaryl propionates via trapping of carbocations with [pi]-nucleophiles, efforts towards the total synthesis of acutumine, and the design, synthesis, and thermodynamics of protein-ligand interactions at the Src SH2 domain
(2013-12)
Heterocyclic alcohols were coupled with [pi]-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate to provide a variety of substituted [beta]-heteroaryl propionates, including those with contiguous ...
Applications of bis(imino)acenaphthene and investigation of boron arsenide as a high thermal conductivity material
(2015-05)
Abstract: Functionalization of the ubiquitous bis(imino)acenaphthene ligand class has been explored. The successful functionalization of this ligand type was found to be dependent upon the steric congestion encompassing ...
Electrocatalytic reduction of oxygen on metal nanoparticles in the absence and presence of interactions with metal-oxide supports
(2018-08-16)
A combined experimental and theoretical approach is reported with a goal to develop a deeper understanding of strong metal support interactions (SMSI) and particularly their role in the oxygen reduction reaction (ORR). ...
Synthesis of top coat surface treatments for the orientation of thin film block copolymers
(2013-08)
Block copolymer self-assembly has demonstrated sub-optical lithographic resolution . High values of chi, the block copolymer interaction parameter, are required to achieve next-generation lithographic resolution . ...
Graphite oxide and its applications in the preparation of small molecules, polymers, and high performance polymer composites
(2012-05)
Graphite oxide (GO), a carbon material prepared in one step from low cost commercial materials, and graphene oxide have been found to catalyze a wide range of reactions including oxidations, hydrations, and dehydrations, ...
Development of microdevices for applications to bioanalysis
(2007)
The development of microdevices for applications related to bioanalysis is described. There are two types of microdevices involved in this study: DNA (or RNA) microarrays and bead-based microfluidic devices. First, a new ...
Differential sensing of kinases.
(2014-05)
During the last decade, organic and supramolecular chemistry in combination with analytical and fluorescent-based sensing methods have led to the development of chemical biology tools to study protein phosphorylation in ...
Engineering highly active enzymes with altered substrate selectivities
(2005)
Two enzyme model systems were employed to address fundamental questions
regarding enzyme engineering via directed evolution. First, it was demonstrated that
highly active glutathione transferases (GST) can be isolated ...