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Development of hydrogen-mediated carbon-carbon bond formations
(2005)
Elemental hydrogen is the cleanest and most cost effective reductant available to
mankind. Although catalytic hydrogenation has been practiced industrially on an
enormous scale, use of hydrogen as a terminal reductant ...
Hydrogen-mediated carbon-carbon bond formations: applied to reductive aldol and Mannich reactions
(2007)
Hydrogen gas is the cleanest and most cost-effective reductant available to mankind, and the use of hydrogen gas in catalytic hydrogenation reactions is one of the oldest and most utilized organic reactions. Although ...
Transition metal and organo-catalyzed cyclizations, cycloadditions and couplings
(2004)
Transition metal-catalyzed carbon-carbon bond-forming reactions are attractive
methodological targets, as they enable the rapid build-up of molecular complexity.
Herein is described research directed toward the development ...
Transition metal-catalyzed reductive C-C bond formation under hydrogenation and transfer hydrogenation conditions
(2008-12)
Carbon-carbon bond forming reactions are vital to the synthesis of natural products and pharmaceuticals. In 2003, the 200 best selling prescription drugs reported in Med Ad News are all organic compounds. Synthesizing these ...
Enones and enals as latent enolates in catalytic C-C bond forming processes : total synthesis of (-)-paroxetine (Paxil®)
(2007-05)
Enolates constitute one of the most commonly utilized intermediates in synthetic
organic chemistry. However, the regioselective generation of enolates remains a
challenge, especially for non-symmetric ketones possessing ...
Synthesis of organic compounds for two-photon initiated polymerization and molecular recognition
(2003)
In section I, three-dimensional polymeric objects were fabricated using
two-photon initiated polymerization (TPIP) with a two-photon absorbing
chromophore and an acrylate resin. The feasibility of fabricating polymeric
features ...
Electrophilic trapping of enolates in tandem reaction processes and (1,3-diketonato)metal templates for asymmetric catalysis
(2004)
The discovery of methods for the catalytic generation of enolates in the presence
of suitable electrophilic partners has led to the development of several effective strategies
for the tandem formation of multiple bonds. ...
Studies toward the total synthesis of quinine
(2008-05)
Quinine is an alkaloid natural product isolated from the bark of the cinchona tree. It has long served as a synthetic target due to its antimalarial properties. The total synthesis of quinine can be envisioned employing a ...
Self-assembly of functionalized synthetic nucleic acid bases
(2005)
Inspired by the significance and utility of hydrogen bond driven self-assembly, as
exemplified through base-pairing interactions of double helical DNA, this dissertation
discusses the synthetic preparation and structural ...
Electroorganic synthesis: inter- and intra-molecular anion radical cycloadditions, and electrogenerated base promoted coupling reactions
(2005)
The electrochemical promotion of a variety of organic synthetic procedures has
been investigated. These procedures are seen to fall into two categories, those promoted
by anion radicals, and those promoted by electrogenerated ...