Browsing UT Electronic Theses and Dissertations by Department "Biomedical Engineering"
Now showing items 1-20 of 282
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A 20-coil array system for high-throughput dynamic contrast-enhanced mouse MRI
(2011-12)MRI is a versatile tool for systematically assessing anatomical and functional changes in small animal models of human disease. Its noninvasive nature makes MRI an ideal candidate for longitudinal evaluation of disease ... -
3D characterization of ventricular myocardium in health, disease, and treatment
(2021-05-07)Cardiovascular diseases such as myocardial infarction and pulmonary arterial hypertension cause maladaptive remodeling of the heart, which drastically alters its function and progresses toward heart failure. Determining ... -
A Förster resonance energy transfer-based sensor of steric pressure generated by protein crowding on membrane surfaces
(2022-08-12)Biological membranes are densely crowded with proteins. Rapid diffusion and collision of membrane-bound proteins generates substantial steric pressure that is capable of shaping membrane surfaces. Despite efforts to model ... -
An apoptotic body-inspired nanoparticle to modulate inflammatory macrophages
(2021-03-15)Chronic inflammation is a significant pathological process found in a range of disease states. Treatments to reduce inflammation in this family of diseases may improve symptoms and disease progression, but are largely ... -
An arborizing, multiport catheter for maximizing drug distribution in the brain via convection enhanced delivery
(2018-08)Glioblastoma (GBM) is a high-grade malignant glioma with a mortality rate that exceeds 95% despite over eight decades of medical research dedicated to improve outcomes. GBM is extremely difficult to treat and practically ... -
An integrated approach to model cancer cell growth and treatment response with multimodal data sources
(2020-06-22)Mathematical modeling and computational biology have been used to understand, describe, and predict critical behaviors of cancer progression. Recent technological advancements in the acquisition of single cell resolution ... -
Anisotropy in cell sheeting and cardiac differentiation
(2018-06-12)Treatment for myocardial infarction is largely limited to alleviating symptoms and preventing recurrence rather than directly repairing or replacing the damaged myocardial tissue. Consequently, one of the overarching goals ... -
Antibody-free isolation of circulating tumor cells by dielectrophoretic field-flow fractionation
(2013-08)This work focuses on the integration of microfluidics and dielectrophoresis(DEP) with the principles of field flow fractionation (FFF) to create a continuous-flow isolator for rare and viable circulating tumor cells (CTCs) ... -
Application of polarization sensitive optical coherence tomography (PS-OCT) and phase sensitive optical coherence tomography (PhS-OCT) for retinal diagnostics
(2011-05)An Enhanced Polarization-Sensitive Swept Source Optical Coherence Tomography (EPS-SS-OCT) instrument for high sensitivity cross-sectional imaging of Retinal Nerve Fiber Layer (RNFL) has been designed, constructed, and ... -
Applications of micro-3D printing to microfluidic cell dosing
(2014-08)Cellular growth, development, differentiation, and death are mediated to some degree by the interaction of soluble factors with plasma membrane receptors. Traditionally the cellular response to chemical cues has been studied ... -
Applications of ultrasound and photoacoustics in the central nervous system
(2017-05)Ultrasound imaging has seen a new resurgence in both clinical and preclinical research as demand for affordable and accessible imaging techniques has increased. There are both therapeutic and imaging applications of ... -
Autofluorescence and diffuse reflectance patterns in cervical spectroscopy
(2005)Fluorescence and diffuse reflectance spectroscopy are two new optical technologies, which have shown promise to aid in the real time, non-invasive identification of cancers and precancers. Spectral patterns carry a ... -
Automated microfluidic platforms to facilitate nerve degeneration studies with C. elegans
(2013-12)With its well-characterized genome, simple anatomy, and vast array of uses in molecular biology, the roundworm, Caenorhabditis elegans (C. elegans) is a well-established model organism in neurobiology. Concurrently, ... -
Automatic segmentation and classification of multiplex-fluorescence in-situ hybridization chromosome images
(2006-08)Multicolor fluorescence in-situ hybridization (M-FISH) techniques provide color karyotyping that allows simultaneous analysis of numerical and structural abnormalities of whole human chromosomes. Chromosomes are stained ... -
The biological basis for changes in autofluorescence during neoplastic progression in oral mucosa
(2007-12)Autofluorescence spectroscopy can improve the early detections of oral cancer. Biochemical and structural changes associated with dysplastic progression alter the optical properties of oral mucosa and cause diagnostically ... -
Biological buffer-mediated self-assembly of modular nucleo-peptide hydrogels for tissue engineering applications
(2021-08-02)Hydrogel scaffolds are at the forefront of tissue engineering research due to several distinct characteristics, namely highly hydrated, diffusive environments and physical and structural characteristics that mimic the ... -
Biomarker for tracking progression of Alzheimer's disease in clinical trials
(2015-08)Currently, there are no treatments available for mitigating the neurological effects of Alzheimer's disease. All clinical trials of disease-modifying treatments, which showed promise in animal models, have failed to show ... -
Biomechanical regulation of cancer metastasis
(2018-06-19)Metastasis is the ultimate cause of most cancer-related deaths. As such, it is critical to understand the processes that control the spread of cancer through the body. To metastasize, cancer cells must leave the primary ... -
Biomedical photoacoustics beyond thermal expansion : photoacoustic nanoDroplets
(2012-05)The recent increase in survival rates of most cancers is due to early detection greatly aided by medical imaging modalities. Combined ultrasound and photoacoustic imaging provide both morphological and functional/molecular ... -
Biophysical basis of skin cancer detection using Raman spectroscopy
(2019-08)The goal of this dissertation is to study the potential of Raman spectroscopy in improving the clinical diagnosis of skin cancer, including two main applications: noninvasive screening of melanoma skin cancer and surgical ...
