Measurement of electrical admittance to study the onset and progression of myocardial ischemia
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The electrical admittance of myocardium can be used to distinguish between stunned, ischemic and necrotic myocardial tissue. Myocardial stunning is the reversible contractile dysfunction following a brief ischemic episode. This reversible nature is clinically significant and is in contrast to the irreversible myocardial dysfunction that occurs with necrosis. This dissertation aims at developing an instrument to measure myocardial admittance during ischemia and subsequent reperfusion and to study the underlying mechanisms governing the onset and progression of ischemia and stunning. The instrument was tested on Langendorff models of the isolated rat heart that has been subjected to varying durations of global no flow ischemia and subsequent reperfusion. The relative permittivity and conductivity of the myocardium was determined and this could be correlated to the state of the tissue.