Dietary fiber linked to decreased inflammation in overweight minority youth
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Objective: To examine the relationship between diet and inflammation, and adiposity in minority youth. Design and Methods: A cross-sectional analysis of 142 overweight (≥85th BMI percentile) Hispanic and African American adolescents (14-18 y) with the following measures: anthropometrics, adiposity via magnetic resonance imagine (MRI), dietary intake via 24-hour dietary recalls, and inflammation markers from fasting blood draws utilizing a multiplex panel. Partial correlations were estimated and ANCOVA models fit to examine the relationship between dietary variables, inflammation markers, and adiposity measures with the following a priori covariates: Tanner stage, ethnicity, sex, total energy intake, total body fat, and total lean mass. Results: Inference based on ANCOVA models showed that the highest tertile of fiber intake (mean intake of 21.3 ± 6.1 g/d) versus the lowest tertile of fiber intake (mean intake of 7.4 ± 1.8 g/d) was associated with 36% lower plasminogen activator inhibitor-1 (PAI-1) (P = 0.02) and 43% lower resistin (P = 0.02), independent of covariates. Similar results were seen for insoluble fiber. No other dietary variables included in this study were associated with inflammation markers. Conclusions: These results suggest that increases in dietary fiber could play an important role in lowering inflammation and therefore metabolic disease risk in high-risk minority youth.