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dc.contributor.advisorMagnus, Philip D.
dc.creatorWells, Charles Eugeneen
dc.date.accessioned2015-05-14T18:09:58Zen
dc.date.available2015-05-14T18:09:58Zen
dc.date.issued2004-05en
dc.identifier.urihttp://hdl.handle.net/2152/29857en
dc.descriptiontexten
dc.description.abstractThis dissertation is devoted to our synthetic studies towards the total synthesis of the natural product Nakadomarin A, and Manzamine A using the Pauson-Khand reaction as the key step. Chapter 1 reviews past work using Pauson-Khand technology. Chapter 2 reviews the N-alkyl piperidine family of natural products. Chapter 3 reviews published total syntheses of Manzamine A and Nakadomarin A. Chapter 4 explores our work using the Pauson-Khand reaction to form the ABC rings of Nakadomarin A and subsequent B ring expansion to form the ABC ring core of Manzamine A. Chapter 5 explores our approaches to the furan portion, as well as, our approaches to the macrocyclic F ring. Finally Chapter 6 contains the description of the experiments performed along with relevant analytical data.en
dc.format.mediumelectronicen
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subjectNakadomarin Aen
dc.subjectTotal synthesisen
dc.subjectManzamine Aen
dc.subjectPauson-Khand reactionen
dc.subjectN-alkyl piperidineen
dc.subjectABC ringen
dc.subjectMacrocyclic F ringen
dc.titleAn approach towards the synthesis of Nakadomarin A and Manzamine A Using Pauson-Khand technologyen
dc.typeThesisen
dc.description.departmentChemistryen
thesis.degree.departmentChemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen
dc.rights.restrictionRestricteden


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