Showing items related by title, author, creator and subject.

• Neurobiological Signatures of Alcohol Dependence Revealed by Protein Profiling 

  Gorini, Giorgio; Roberts, Amanda J.; Mayfield, Dayne R. (PLOS One, 2013-12-16)

  Alcohol abuse causes dramatic neuroadaptations in the brain, which contribute to tolerance, dependence, and behavioral modifications. Previous proteomic studies in human alcoholics and animal models have identified candidate ...

• Identification of Novel Substrates of Protein Kinase C epsilon Using a Chemical Genetic Strategy 

  Shah, Yesha (2018)

  Alcohol use disorder (AUD) is a major public health problem in the United States, and only three drugs are approved to treat it: Disulfuram, naltrexone, and acamprosate. However, these drugs have small effect sizes and ...

• Role of the IKKβ/NF-κB pathway in alcoholism 

  Truitt, Jay Michael; 0000-0001-6272-5582 (2015-08-14)

  Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, ...