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dc.creatorBhadra, Sanchitaen
dc.creatorLozano, Mary Men
dc.creatorPayne, Shelley Men
dc.creatorDudley, Jaquelin Pen
dc.identifier.citationBhadra S, Lozano MM, Payne SM, Dudley JP (2006) Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens. PLoS Pathog 2(12): e128. doi:10.1371/journal.ppat.0020128en
dc.description.abstractMost inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. Infection of Mtv-null mice with an MMTV-related retrovirus, type B leukemogenic virus, also resulted in severely reduced viral loads and failure to induce T-cell lymphomas, indicating that resistance is not dependent on expression of a superantigen (Sag) encoded by exogenous MMTV. Resistance to MMTV in Mtv-null animals was not due to neutralizing antibodies. Further, Mtv-null mice were resistant to rapid mortality induced by intragastric inoculation of the Gram-negative bacterium, Vibrio cholerae, but susceptibility to Salmonella typhimurium was not significantly different from BALB/c mice. Susceptibility to both MMTV and V. cholerae was reconstituted by the presence of any one of three endogenous Mtvs located on different chromosomes and was associated with increased pathogen load. One of these endogenous proviruses is known to encode only Sag. Therefore, Mtv-encoded Sag appears to provide a unique genetic susceptibility to specific viruses and bacteria. Since human endogenous retroviruses also encode Sags, these studies have broad implications for pathogen-induced responses in mice and humans.en
dc.description.sponsorshipThis work was supported by the Foundation for Research and by the National Institutes of Health R01 CA77760.en
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.subjectBacterial pathogensen
dc.subjectCell-mediated immunityen
dc.subjectDisease susceptibilityen
dc.subjectImmune responseen
dc.subjectReverse transcriptase-polymerase chain reactionen
dc.subjectT cellsen
dc.subjectVibrio choleraeen
dc.titleEndogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogensen

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States