Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans
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In eukaryotes, gene expression is a complex, multi-step process involving transcription, splicing, translation, and post-translational modifications. At each individual step, errors can occur that lead to nonfunctional and potentially toxic proteins. Therefore, eukaryotes have evolved a wide array of solutions to minimize the risk of error.
CitationWilke CO (2011) Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans. PLoS Genet 7(10): e1002296. doi:10.1371/journal.pgen.1002296
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