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dc.creatorSwindell, William R.en
dc.creatorJohnston, Andrewen
dc.creatorCarbajal, Steveen
dc.creatorHan, Gangwenen
dc.creatorWohn, Christianen
dc.creatorLu, Junen
dc.creatorXing, Xianyingen
dc.creatorNair, Rajan P.en
dc.creatorVoorhees, John J.en
dc.creatorElder, James T.en
dc.creatorWang, Xiao-Jingen
dc.creatorSano, Shigetoshien
dc.creatorPrens, Errol P.en
dc.creatorDiGiovanni, Johnen
dc.creatorPittelkow, Mark R.en
dc.creatorWard, Nicole L.en
dc.creatorGudjonsson, Johann E.en
dc.identifier.citationSwindell WR, Johnston A, Carbajal S, Han G, Wohn C, et al. (2011) Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis. PLoS ONE 6(4): e18266. doi:10.1371/journal.pone.0018266en
dc.descriptionWilliam R. Swindell is with Harvard Medical School, Andrew Johnston is with University of Michigan Medical School, Steve Carbajal is with UT Austin, Gangwen Han is with University of Colorado, Christian Wohn is with University Medical Center Rotterdam, Jun Lu is with the Mayo Clinic, Xianying Xing is with University of Michigan Medical School, Rajan P. Nair is with University of Michigan Medical School, John J. Voorhees is with University of Michigan Medical School, James T. Elder is with University of Michigan Medical School and Ann Arbor Veterans Affairs Hospital, Xiao-Jing Wang is with University of Colorado, Shigetoshi Sano is with Kochi Medical School, Errol P. Prens is with University Medical Center Rotterdam, John DiGiovanni is with UT Austin, Mark R. Pittelkow is with the Mayo Clinic, Nicole L. Ward is with Case Western Reserve University and University Hospitals, Johann E. Gudjonsson is with University of Michigan Medical School.en
dc.description.abstractDevelopment of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression patterns manifested by human psoriatic skin lesions with those that occur in five psoriasis mouse models (K5-Tie2, imiquimod, K14-AREG, K5-Stat3C and K5-TGFbeta1). While the cutaneous gene expression profiles associated with each mouse phenotype exhibited statistically significant similarity to the expression profile of psoriasis in humans, each model displayed distinctive sets of similarities and differences in comparison to human psoriasis. For all five models, correspondence to the human disease was strong with respect to genes involved in epidermal development and keratinization. Immune and inflammation-associated gene expression, in contrast, was more variable between models as compared to the human disease. These findings support the value of all five models as research tools, each with identifiable areas of convergence to and divergence from the human disease. Additionally, the approach used in this paper provides an objective and quantitative method for evaluation of proposed mouse models of psoriasis, which can be strategically applied in future studies to score strengths of mouse phenotypes relative to specific aspects of human psoriasis.en
dc.description.sponsorshipThis work was supported by the Babcock Endowment to Dr. Gudjonsson and Dr. Johnston, the Taubman Medical Research Institute support (Frances and Kenneth Eisenberg Emerging Scholar) and the Dermatology Foundation to Dr. Gudjonsson. The project described was supported by NIH grant number CA76520 to Dr. DiGiovanni, AR052889 and AR054966 to Dr. Elder, GM70966, CA79998 and CA89849 to Dr. Wang and P30AR39750 and P50AR05508, National Psoriasis Foundation and the Murdough Family Center for Psoriasis to Dr. Ward. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.subjectGene expressionen
dc.subjectMouse modelsen
dc.titleGenome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasisen

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Attribution 3.0 United States
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