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dc.contributor.advisorMagnus, Philip D.en
dc.creatorHarrington, Ryan Matthew, 1980-en
dc.date.accessioned2012-09-21T16:44:57Zen
dc.date.available2012-09-21T16:44:57Zen
dc.date.issued2008-05en
dc.identifier.urihttp://hdl.handle.net/2152/17960en
dc.descriptiontexten
dc.description.abstractHerein describes our approaches to the Daphniphyllum alkaloids. Specifically targeted are the recently isolated daphnicyclidins. The first chapter describes the structural diversity and biological properties of this class of alkaloids. Chapter 2 discusses some exploratory chemistry towards the daphnicyclidin fused tricycle. Chapter 3 describes the use of cyclopropanes in synthesis and their use in our ring expansion strategy. Preliminary results on the key cyclopropane ring expansion and the stereoselective quaternary center formation are also discussed. The chemistry concerning the diasteroselective cyclopropanation of a key intermediate and further details concerning the cyclopropane ring expansion are delineated. Chapter 4 contains the experimental details and characterization data for all new reported compounds.en
dc.format.mediumelectronicen
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subject.lcshAlkaloids--Synthesisen
dc.subject.lcshAlkaloidsen
dc.subject.lcshCyclopropaneen
dc.titleStudies on the Daphniphyllum alkaloids : strategies towards the synthesis of daphnicyclidin alkaloidsen
dc.description.departmentChemistryen
thesis.degree.departmentChemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen


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