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dc.contributor.advisorSessler, Jonathan L.en
dc.creatorEller, Leah Reneeen
dc.date.accessioned2008-08-28T22:05:42Zen
dc.date.available2008-08-28T22:05:42Zen
dc.date.issued2005en
dc.identifierb59832630en
dc.identifier.urihttp://hdl.handle.net/2152/1542en
dc.descriptiontexten
dc.description.abstractThe transport of an anion across a lipid bilayer or the extraction of an anion into organic solution requires the stabilization of a charged species in a hydrophobic environment. Due to the similar energetic barriers of both processes, liquid-liquid extraction can potentially be used as a model for membrane transport. Carrier species that can efficiently extract anions from aqueous solutions into solvents such as chloroform, can potentially be utilized to facilitate the diffusion of those anions across a lipid bilayer or cell membrane. The research presented here explores the relationship between liquid-liquid extraction and membrane transport behavior. Chapter 1 presents an introduction to the equilibria reactions that are involved in extraction, the structure of lipid bilayers and a description of liposome models of cell membranes. Chapter 2 details the partitioning analysis of sulfate using radiotracers. Chapter 3 explores the chloride extraction behavior of several pyrrole-based molecules using radiotracer analysis. Chapter 4 details the extensive studies of chloride transport across lipid bilayers using liposome model membranes.
dc.format.mediumelectronicen
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subject.lcshCell membranesen
dc.subject.lcshBiological transporten
dc.subject.lcshChlorides--Physiological transporten
dc.titleAnions in hydrophobic environments: liquid-liquid extraction of sulfate and chloride, and membrane transport of chlorideen
dc.description.departmentChemistry and Biochemistryen
dc.description.departmentChemistryen
dc.identifier.oclc61224503en
dc.type.genreThesisen
thesis.degree.departmentChemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen


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