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dc.contributor.advisorAndrew D. Ellington
dc.creatorEckhoff, Grace
dc.date.accessioned2011-09-06T17:25:38Z
dc.date.available2011-09-06T17:25:38Z
dc.date.created2010-05
dc.date.issued2011-09-06
dc.identifier.urihttp://hdl.handle.net/2152/13411
dc.description.abstractTuberculosis is one of the most ancient human pathogens. Very early in the history of humans, tuberculosis spread throughout the world and currently infects one third of the world’s population1. Tuberculosis, both as a pathogen and a disease state, is fascinating in its own right. Considering the global public health significance of tuberculosis, which infects one third of the world’s population and kills over 1.5 million people per year, tuberculosis remains a threat and demands further research. For these reasons, my undergraduate research has largely centered on tuberculosis. Chapter 1 gives a broad overview of tuberculosis, applicable but not specific to my research. Each subsequent chapter focuses on a research project, with relevant additional background on tuberculosis. Chapter 2 is based on an internship at the Texas Department of State Health Services analyzing reasons for delayed completion of tuberculosis therapy for patients whose therapy initiated in Texas in 2006. Chapter 3 examines the potential for molecular methods of tuberculosis in low-resource setting, building off of my experience using mutations in the rpoB gene as a surrogate marker of rifampin resistance in Afghanistan. Chapter 4 briefly expands upon further work done in the lab of Dr. Andrew Ellington at the University of Texas at Austin under the supervision of Xi Chen, developing non-enzymatic methods of nucleic acid detection to indicate the presence of tuberculosis and other pathogens.en_US
dc.language.isoengen_US
dc.subjectCollege of Natural Sciencesen_US
dc.subjecttuberculosisen_US
dc.subjecttherapyen_US
dc.subjectrifampin resistanceen_US
dc.subjectTexasen_US
dc.subjectAfghanistanen_US
dc.subjectrpoB geneen_US
dc.subjectnucleic acid detectionen_US
dc.titleThe challenges and opportunities in tuberculosis control, from Texas to Afghanistanen_US
dc.typeThesisen_US
dc.description.departmentBiological Sciences, School ofen_US


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