|dc.description.abstract||Backgrounds: Epidemiological studies show that alcohol consumption increases breast cancer
risk. However, the mechanism by which alcohol causes this effect is not known. Therefore, our
objective is to generate an animal model to find the mechanism by which alcohol increases
breast cancer risk.
Methods: To determine the effects of alcohol consumption on breast cancer development, 65
female FVB/N mice were randomized (30-water, 35-alcohol) to have free access to water or 20%
alcohol. All mice were given the same diet and placed in similar living conditions. Eleven weeks
into the study, mice were injected with Met-1 mammary cancer cells subcutaneously in their
backs. We measured body weight, food, liquid consumption, and tumor growth rate throughout
the study. To determine body composition, mice were scanned using a GE Lunar Piximus
Densitometer, which measures percent body fat, percent lean body mass, and bone mineral
Results: Results showed that tumor development is exacerbated in the alcohol consuming mice.
Alcohol consuming mice developed tumors earlier than water consuming mice. Furthermore,
tumors in the alcohol consuming mice were larger in volume. Body weights, caloric
consumption, and body composition showed no significant difference between the alcohol and
water consuming mice.
Conclusion: We present a suitable animal model where we can elucidate the mechanism by
which alcohol consumption promotes mammary tumor development.||en