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Optimizing the production of and engineering polyketide synthases
Polyketide synthases are enormous modular enzymes that synthesize large acyl chains known as polyketides. Common polyketides include pharmaceuticals such as antibiotics, immunosuppressants, and antifungals1. The mechanism ...
Investigation of c-Jun N-terminal Kinase 2 Regulation
JNK2). This protein is unique in that it can autophosphorylate, or phosphorylate itself. It was found that these proteins tend to form aggregates of four, or tetramers, when inactive and remain as single units, or monomers, ...
Targeting a Critical Enzyme to Combat Bubonic Plague
Yersinia pestis is the bacterium that causes plague infection, which continues to be prevalent in rural areas of the world. Moreover, because pneumonic plague has a high mortality rate even with antibiotic therapy, aerosolized ...
Progress in the search for histidine acid phosphatase inhibitors in Francisella tularensis
Histidine acid phosphatase (hap) is an important enzyme in the bacteria Francisella Tularensis that is responsible for the cleavage of phosphate groups from phosphorylated proteins. Here, we report on the process for ...
Programmable Three-Dimensional Self-Assembly
The development of modern technology has emphasized the utility of nanomaterials and efficient design of nanostructures. Self-assembly is a powerful, bottom-up approach for the fabrication of nanomaterials. The Hammer and ...