Now showing items 1-5 of 5
miRNA-Dependent Translational Repression in the Drosophila Ovary
(Public Library of Science, 2009-03-02)
Background: The Drosophila ovary is a tissue rich in post-transcriptional regulation of gene expression. Many of the regulatory factors are proteins identified via genetic screens. The more recent discovery of microRNAs, ...
The Retrohoming of Linear Group II Intron RNAs in Drosophila melanogaster Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms
(Public Library of Science, 2012-02-16)
Mobile group II introns are bacterial retrotransposons that are thought to have invaded early eukaryotes and evolved into introns and retroelements in higher organisms. In bacteria, group II introns typically retrohome via ...
Bmp and Shh Signaling Mediate the Expression of satb2 in the Pharyngeal Arches
(Public Library of Science, 2013-03-21)
In human, mutation of the transcription factor SATB2 causes severe defects to the palate and jaw. The expression and sequence of SATB2 is highly conserved across vertebrate species, including zebrafish. We sought to ...
Group II Intron-Based Gene Targeting Reactions in Eukaryotes
(Public Library of Science, 2008-09-01)
Background: Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the ...
Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent
(Public Library of Science, 2012-08-21)
Studies in diverse organisms have revealed a surprising depth to the evolutionary conservation of genetic modules. For example, a systematic analysis of such conserved modules has recently shown that genes in yeast that ...