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dc.contributor.advisorMagnus, Philip D.en
dc.creatorKreisberg, Jennifer Dianeen
dc.date.accessioned2011-03-23T21:26:21Zen
dc.date.available2011-03-23T21:26:21Zen
dc.date.issued2001-12en
dc.identifier.urihttp://hdl.handle.net/2152/10661en
dc.descriptiontexten
dc.description.abstractThis dissertation is devoted to our synthetic studies aimed at the total synthesis of the natural product diazonamide A. Chapter 1 serves as an introduction to the diazonamides with a discussion of related marine cyclopeptides, previous synthetic work, and our retrosynthetic analysis. In Chapter 2, the development of a methodology for constructing benzofuran-2-ones related to the IHG-rings of diazonamide A using the Pummerer reaction is presented. Chapter 3 describes the preparation of bis-benzylic radicals and an examination of their chemical properties. A new methodology for the synthesis of 2,4-disubstituted oxazoles is reported in Chapter 4. Chapter 5 details the synthesis of several advanced model systems including the completion of the IHGCDEFrings. Finally, Chapter 6 contains a description of the experiments performed along with the relevant analytical data.
dc.format.mediumelectronicen
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subjectStereochemistryen
dc.subjectDiazonamide Aen
dc.titleStudies directed towards the total synthesis of the natural product diazonamide Aen
dc.description.departmentChemistry and Biochemistryen
thesis.degree.departmentChemistry and Biochemistryen
thesis.degree.disciplineChemistryen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen
dc.rights.restrictionRestricteden


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