• Characterizing dynein in T cells 

    Tan, Sarah Youngsun (2010-11-23)
    T cells play pivotal roles in the immune system and focused secretion of either cytokines or cytotoxic molecules toward its target is crucial for T cell functions. This directional secretion involves two critical steps: ...
  • Imaging molecular motor regulation at the single molecule level 

    Walther, Juergen Herbert (2013-12-05)
    Molecular motor proteins are responsible for the long range transport of vesicles and organelles inside living cells. A small number of motor types transport thousands of distinct cargoes to various regions in the cell at ...
  • Measuring molecular motor forces to probe transport regulation in vivo 

    Leidel, Christina Paulette (2013-07-09)
    The cell relies on molecular motor proteins for long range transport of vesicles and organelles to maintain the organization required within the cell as it changes over time. Cargos move bidirectionally along microtubules ...
  • Probing the coupling mechanism of opposite polarity motors 

    Holzmeister, Phil Jack (2011-11-02)
    Molecular motors are responsible for all long range transport and organization of organelles within cells. However, little is known about the interaction of multiple similar and dissimilar motors. In this thesis I describe ...
  • The roles of dynein and dynein accessory proteins in T cell effector functions 

    Christian, Laura Manno (2013-02-26)
    T cell effector functions depend on focused secretion. This is accomplished by secretory vesicle (SV) clustering around the microtubule organizing center (MTOC) and MTOC translocation to the specialized site of cell-cell ...