Browsing by Subject "Drugs--Metabolism"
Now showing items 1-3 of 3
(2002-08)Immunosuppressant cyclosporine (CsA) is primarily metabolized by cytochrome P450 3A (CYP3A), and a substrate for P-glycoprotein (P-gp). The large variability in CsA pharmacokinetics makes predicting CsA effects and toxicity ...
(2005)Recombinant adenovirus serotype 5 (Ad) is a key vector extensively employed in gene therapy clinical trials and vaccine development protocols. Although this vector has a natural tropism for the liver, there is limited ...