• Drug-Induced Epigenetic Changes Produce Drug Tolerance 

    Wang, Yan; Krishnan, Harish R; Ghezzi, Alfredo; Yin, Jerry C. P; Atkinson, Nigel S. (Public Library of Science, 2013-05-28)
    Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important ...
  • Mechanisms of benzyl alcohol tolerance in Drosophila melanogaster 

    Alhasan, Yazan Mahmoud (2010-08-19)
    Proper neuronal function requires the preservation of appropriate neural excitability. An adaptive increase in neural excitability after exposure to agents that depress neuronal signaling blunts the sedative drug effects ...