• A Comparative Analysis of Influenza Vaccination Programs 

    Bansal, Shweta; Pourbohloul, Babak; Meyers, Lauren Ancel (Public Library of Science, 2013-06-28)
    Background -- The threat of avian influenza and the 2004–2005 influenza vaccine supply shortage in the United States have sparked a debate about optimal vaccination strategies to reduce the burden of morbidity and mortality ...
  • DNA-based molecular circuits for diagnostics and therapeutics 

    Codrea, Vlad Alexandru (2013-08-16)
    Nucleic acids are a uniquely flexible and multi-faceted class of molecules that fulfill fundamental and defining tasks such as replication and determination of heritable characteristics in every living organism. From the ...
  • Epidemic dynamics in heterogeneous populations 

    Hladish, Thomas Joseph (2012-11-13)
    Epidemiological models traditionally make the assumption that populations are homogeneous. By relaxing that assumption, models often become more complicated, but better representations of the real world. Here we describe ...
  • Erratic Flu Vaccination Emerges from Short-Sighted Behavior in Contact Networks 

    Cornforth, Daniel M.; Reluga, Timothy C.; Shim, Eunha; Bauch, Chris T.; Galvani, Alison P.; Meyers, Lauren Ancel (Public Library of Science, 2013-06-28)
    The effectiveness of seasonal influenza vaccination programs depends on individual-level compliance. Perceptions about risks associated with infection and vaccination can strongly influence vaccination decisions and thus ...
  • Identification of the Influenza A nucleoprotein sequence that interacts with the viral polymerase 

    Marklund, Jesper Karl (2013-01-15)
    Influenza A is a negative stranded RNA virus with a segmented genome. Once the virus infects a cell it must replicate its full length viral genomic RNA (vRNA) through a positive sense complementary intermediate RNA (cRNA) ...
  • Modeling the structure, dynamics, and interactions of biological molecules 

    Xia, Zhen, active 2013 (2013-03-28)
    Biological molecules are essential parts of organisms and participate in a variety of biological processes within cells. Understanding the relationship between sequence, structure, and function of biological molecules are ...
  • Optimizing Provider Recruitment for Influenza Surveillance Networks 

    Scarpino, Samuel V.; Dimitrov, Nedialko B.; Meyers, Lauren Ancel (Public Library of Science, 2013-06-26)
    The increasingly complex and rapid transmission dynamics of many infectious diseases necessitates the use of new, more advanced methods for surveillance, early detection, and decision-making. Here, we demonstrate that a ...
  • Optimizing Tactics for Use of the U.S. Antiviral Strategic National Stockpile for Pandemic Influenza 

    Dimitrov, Nedialko B.; Goll, Sebastian; Hupert, Nathaniel; Pourbohloul, Babak; Meyers, Lauren Ancel (Public Library of Science, 2013-06-28)
    In 2009, public health agencies across the globe worked to mitigate the impact of the swine-origin influenza A (pH1N1) virus. These efforts included intensified surveillance, social distancing, hygiene measures, and the ...
  • Overlooked casualties : stories of families affected by vaccine-preventable diseases 

    Haelle, Tara Susan (2012-08-15)
    The invention of the vaccine has been one of the greatest public health triumphs of the modern world. Each new vaccine has saved thousands - even millions - of lives worldwide, but this success has been fraught with ...
  • The Shifting Demographic Landscape of Pandemic Influenza 

    Bansal, Shweta; Pourbohloul, Babak; Hupert, Nathaniel; Grenfell, Bryan; Meyers, Lauren Ancel (Public Library of Science, 2013-06-28)
    Background -- As Pandemic (H1N1) 2009 influenza spreads around the globe, it strikes school-age children more often than adults. Although there is some evidence of pre-existing immunity among older adults, this alone may ...