Browsing by Department "Molecular Biosciences"
Now showing items 1-20 of 91
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Alpha-TEA-Induced Death Receptor Dependent Apoptosis Involves Activation of Acid Sphingomyelinase and Elevated Ceramide-Enriched Cell Surface Membranes
(2010-10)Background: Alpha-tocopherol ether-linked acetic acid (alpha-TEA), an analog of vitamin E (RRR-alpha-tocopherol), is a potent and selective apoptosis-inducing agent for human cancer cells in vivo and in vitro. alpha-TEA ... -
Antibiotic Markers: An Overlooked Design Choice in Synthetic Biology?
(2021)Synthetic biology seeks to engineer living systems to enhance human health, improve material synthesis and degradation, and simplify diagnostics. When researchers design synthetic constructs, they rely on predictable host ... -
ArrayPlex: distributed, interactive and programmatic access to genome sequence, annotation, ontology, and analytical toolsets
(Genome Biology, 2008-11-12)ArrayPlex is a software package that centrally provides a large number of flexible toolsets useful for functional genomics, including microarray data storage, quality assessments, data visualization, gene annotation ... -
Bimodal Signatures of Germline Methylation are Linked with Gene Expression Plasticity in the Coral Acropora Millepora
(2014-12)In invertebrates, genes belonging to dynamically regulated functional categories appear to be less methylated than "housekeeping" genes, suggesting that DNA methylation may modulate gene expression plasticity. To date, ... -
Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis
(Mobile DNA Journal, 2014-01-13)Mobile group II introns are bacterial retrotransposons that combine the activities of an autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert site-specifically into DNA. They recognize ... -
Building a hybrid modular polyketide synthase to investigate ketosynthase selectivity
(2023)Polyketides are a diverse class of molecules which are biosynthesized in many different organisms, such as bacteria, fungi, plants, and animals. They are biologically active compounds and are often harnessed for pharmacological ... -
The CIAP – Aptamer Complex: A Potential System for cDNA Detection
(2018-05)Current detection methods for gene expression include the Northern blot, qPCR, and microarrays, which all come with a unique set of disadvantages. Thus the creation of an alternative gene expression detection system is ... -
The contractile vacuole in Ca2+-regulation in Dictyostelium: its essential function for cAMP-induced Ca2+-influx
(BMC Developmental Biology, 2006-06-20)Background: cAMP-induced Ca2+-influx in Dictyostelium is controlled by at least two non-mitochondrial Ca2+-stores: acidic stores and the endoplasmic reticulum (ER). The acidic stores may comprise the contractile vacuole ... -
The CREATE Approach to Primary Literature Shifts Undergraduates' Self-Assessed Ability to Read and Analyze Journal Articles, Attitudes about Science, and Epistemological Beliefs
(2011-12)The C. R. E. A. T. E. (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) method uses intensive analysis of primary literature in the undergraduate classroom to demystify and ... -
The CREATE Strategy for Intensive Analysis of Primary Literature can be Used Effectively by Newly Trained Faculty to Produce Multiple Gains in Diverse Students
(2014-06)The CREATE (Consider Read, Elucidate the hypotheses, Analyze and interpret the data, and Think of the next Experiment) strategy aims to demystify scientific research and scientists while building critical thinking, ... -
Crystallization And Preliminary X-Ray Analysis Of A Chitinase From The Fungal Pathogen Coccidioides Immitis
(1998-11)Chitinase is necessary for fungal growth and cell division and, therefore, is an ideal target for the design of inhibitors which may act as antifungal agents. A chitinase from the fungal pathogen Coccidioides immitis has ... -
Crystallographic Study Of The Phosphoethanolamine Transferase EptC required For Polymyxin Resistance And Motility In Campylobacter jejuni
(2014-10)The foodborne enteric pathogen Campylobacter jejuni decorates a variety of its cell-surface structures with phosphoethanolamine (pEtN). Modifying lipid A with pEtN promotes cationic antimicrobial peptide resistance, whereas ... -
Current Anti-Ageing Research and Its Potential Implications for Ageism
(2020-05)Although still in its infancy, anti-ageing research has both breadth and depth. Currently, hundreds of researchers are interested in delaying the ageing process and extending lifespan, and there are already several ... -
Detecting Structural Variation in Evolved Bacterial Genomes Using Paired-End DNA Sequencing Data
(2022-05)Structural variants are large-scale genome rearrangement events, such as chromosomal inversions, duplications, and deletions, that can lead to innovative evolution that is not possible with point mutations. They can be ... -
Determining an effective method to select and observe an algae-bacteria symbiosis to bioremediate fluoranthene
(2023-04)Bioremediation is the use of microorganisms to break down anthropogenic chemicals and is a sustainable and more rapid alternative to chemical decomposition. Fluoranthene is one of many polycyclic aromatic hydrocarbons ... -
Determining the region of Rpl10 crucial for Nmd3 release in the 60S subunit pathway of ribosomal biogenesis
(2012-04-27)The large ribosomal subunit of the ribosome is exported out of the nucleus with the help of a protein known as Nmd3. Nmd3 interacts with the large ribosomal subunit and provides a nuclear export signal, which recruits ... -
DISC1 is needed for the organization of cellular components at the immunological synapse.
(2019-04)T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular ... -
The discovery of novel proteins involved in cell polarity and the PAR complex in c. elegans
(2021)Cell polarity is a phenomenon that occurs within nearly all organisms. Characterized by the localization of different proteins to different ends of a cell, this process is extremely important for proper biological development. ... -
Distinct Antiviral Responses in Pluripotent versus Differentiated Cells
(PLOS Pathogens, 2014-02-06)There is a mystery unfolding, the solution of which has implications for the understanding of both stem cell biology and the evolution of the vertebrate pathogen defense response. At the heart of this puzzle lies the ...
