Browsing by Department "Biochemistry"
Now showing items 1-20 of 172
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1,1 ',1 ''-{ 4-(3,4-Ethylenedioxythiophen-2-Yl)Phenyl Methanetriyl}Tris(1H-Pyraz Ole)
(2011-11)In the title complex, C22H18N6O2S, two of the pyrazole rings are disordered over two sets of sites with ratios of refined occupancies of 0.58 (2):0.42 (2) and 0.517 (12):0.483 (12). The dioxane ring is in a half-chair ... -
3-Dimensional Structure Of A Hemichrome Hemoglobin From Caudina arenicola
(1995-09)The structure of a monomeric hemichrome form of an invertebrate hemoglobin, Hb-C chain, from Caudina arenicola has been refined to an R value of 0.16 using the data from 5.0 to 2.5 Angstrom resolution (R = 0.21 from 10.0 ... -
4- Tris(1H-Pyrazol-1-Yl)Methyl Phenol
(2011-11)The title compound, C16H14N6O, was prepared by the condensation of 4-(trifluoromethyl) phenol and sodium pyrazol-1-ide in a yield of 58%. The dihedral angles formed by the planes of the pyrazole rings are 50.7 (2), 71.2 ... -
Alkane-induced expression, substrate binding profile, and immunolocalization of a cytochrome P450 encoded on the nifD excision element of Anabaena 7120
(BMC Microbiology, 2005-03-24)Background: Alkanes have been hypothesized to act as universal inducers of bacterial cytochrome P450 gene expression. We tested this hypothesis on an unusual P450 gene (cyp110) found on a conserved 11 kilobase episomal DNA ... -
Application of enzymatic catalysis and galvanic processes for biosensor development
(2011-08)Methods for integrating enzyme systems with electrochemical reactions having applications to diagnostic sensing are described. Diagnostic tests that include biological molecules can be classified as biosensors. Existing ... -
Approaches to discover new human disease models through Boolean relationships of orthologous phenotypes
(2012-04-26)In the development of genome-wide databases of model organisms, non-traditional approaches to study genomic networks have emerged to model molecular interactions. Past approaches to model such systems have used the homology ... -
Aptamer antagonists of myelin promote axon growth
(2009)Myelin of the adult central nervous system (CNS) is one of the major sources of inhibition to axon regeneration following injury. The three known myelin-derived inhibitors (Nogo, MAG, and OMgp) bind with high affinity ... -
Aptamer Antagonists of Myelin-Derived Inhibitors Promote Axon Growth
(Public Library of Science, 2010-03-16)Myelin of the adult central nervous system (CNS) is one of the major sources of inhibitors of axon regeneration following injury. The three known myelin-derived inhibitors (Nogo, MAG, and OMgp) bind with high affinity to ... -
Avidity effects of MinE07, an anti-EGFR aptamer, on binding to A431 cells
(2010)Cell growth, differentiation, and proliferation are all carefully regulated processes. Disruptions in these processes are often associated with malignant tumors. The epidermal growth factor receptor (EFGR), part of the ... -
A Base Induced Transformation Of A 1,3-Dimethyl-1,3-Di-(1-Adamantyl)Formamidinium Salt Into Beta- Methyl-(1-Adamantyl)Amino Acrylonitriles In Aliphatic Nitriles
(2012)A novel 1,3-dimethyl-1,3-di-(1-adamantyl)formamidinium perchlorate has been prepared via the Vilsmeier-Haack reaction of N-methyl-N-(1-adamantyl)formamide and N-methyl-N-(1-adamantyl) amine in a mixture of phosphorus ... -
Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy-driven DNA amplifier
(Journal of Systems Chemistry, 2010-10-01)The programmability and replicability of RNA and DNA have respectively enabled the design and selection of a number of allosteric ribozymes and deoxyribozymes. These catalysts have been adapted to function as signal ... -
Binding Of Flexible And Constrained Ligands To The Grb2 Sh2 Domain: Structural Effects Of Ligand Preorganization
(2010-10)Structures of the Grb2 SH2 domain complexed with a series of pseudopeptides containing flexible (benzyl succinate) and constrained (aryl cyclopropanedicarboxylate) replacements of the phosphotyrosine (pY) residue in ... -
Biocatalytic Synthesis of Stereospecific Triketide Lactones using Polyketide Synthases
(2016)Polyketide synthases are modular enzymes that create and modify large acyl chains. The domains and modules of polyketide synthases allow us to create molecules that resemble naturally occurring products by applying a ... -
Biochemical characterization of monoclonal antibodies to the Bordetella pertussis Filamentous hemagglutinin (FHA) and Pertussis toxin (PTx) : implications for improved acellular pertussis vaccine design
(2015-08-28)Incidence rates of whooping cough were dramatically decreased by immunization with whole cell pertussis (wP) vaccines in the 1940s. However, concerns about the safety of the wP vaccine resulted in development of new pertussis ... -
Biomaterial-based ligand presentation to induce notch signaling in vitro
(2013)T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native ... -
Biophysical studies of two key regulatory proteins of the translation initiation pathway
(2005)Translation is the process by which proteins are synthesized on the ribosome according to the nucleotide code provided by the mRNA. This highly sophisticated multistep process is tightly regulated at many levels. One of ... -
Biosynthesis of coenzyme M and the catabolism of halogenated aromatic compounds
(2012-12)Methanogens, members of the domain Archaea, are unique in their ability to reduce carbon substrates to methane. Coenzyme M (CoM) is required in all methanogenic pathways. The biosynthesis of this coenzyme has been well ... -
Biosynthesis of sulfur containing heterocycles in natural products
(2016-12)This thesis is a comprehensive review of the biosynthesis of sulfur containing heterocycles in natural metabolites. The review focuses on sulfur incorporation and cyclization of the moieties, with a lesser examination of ... -
Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes
(Genome Biology, 2007-12-05)We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability ...
