Browsing by Subject "replacement"
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Item Letter to E.W. Berry from H.B. Stenzel on 1940-12-16(1940-12-16) Stenzel, Henryk B.Item Letter to J.Brian Eby from John B. Reeside on 1943-05-03(1943-05-03) Reeside, John B.Item Structure Of Ns1A Effector Domain From The Influenza A/Udorn/72 Virus(2009-01) Xia, Shuangluo; Monzingo, Arthur F.; Robertus, Jon D.; Xia, Shuangluo; Monzingo, Arthur F.; Robertus, Jon D.The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented.