Browsing by Subject "click chemistry"

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    Programmable Three-Dimensional Self-Assembly
    (2015) Glazener, William Stanton; Willson, Carlton Grant
    The development of modern technology has emphasized the utility of nanomaterials and efficient design of nanostructures. Self-assembly is a powerful, bottom-up approach for the fabrication of nanomaterials. The Hammer and Tongs method that we have developed signifies the advent of a holistic approach to programmable, three-dimensional self-assembly. This method integrates biochemistry and chemical engineering techniques to create DNA-mediated, self-assembling polymer cubes. Selective functionalization of cubic faces with complimentary DNA sequences provides a programmable route for self-assembly. The development of this method and its process steps demonstrates the potential to form complex structures on extremely small scales.
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    Synthesis of 2-Substituted 9-Oxa-Guanines {5-Aminooxazolo 5,4-D Pyrimidin-7(6H)-Ones} and 9-Oxa-2-Thio-Xanthines{5-Mercaptooxazolo 5,4-D Pyrimidin-7(6H)-Ones}
    (2008-07) Mandal, Subrata; Li, Wen Tai; Bai, Yan; Robertus, Jon D.; Kerwin, Sean M.; Mandal, Subrata; Li, Wen Tai; Bai, Yan; Robertus, Jon D.; Kerwin, Sean M.
    Oxazolo[5,4-d] pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives. In particular, 5-aminooxazolo[5,4-d]pyrimidine-7(6H)-ones (9-oxa-guanines) have been shown to inhibit ricin. The preparation of a series of 2-substituted 5-aminooxazolo[5,4-d] pyrimidin-7(6H)-ones and related 5-thio-oxazolo[5,4-d] pyrimidines is described, including analogs suitable for further elaboration employing "click" chemistry utilizing copper-catalyzed Huisgen 1,3-dipolar cycloadditions. Two of the compounds prepared were found to inhibit ricin with IC(50) ca. 1-3 mM.