Browsing by Subject "bone replacement"

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Effect of Architecture and Porosity on Mechanical Properties of Borate Glass Scaffolds Made by Selective Laser Sintering
(University of Texas at Austin, 2013) Kolan, Krishna C.R.; Leu, Ming C.; Hilmas, Gregory E.; Comte, Taylor
The porosity and architecture of bone scaffolds, intended for use in bone repair or replacement, are two of the most important parameters in the field of bone tissue engineering. The two parameters not only affect the mechanical properties of the scaffolds but also aid in determining the amount of bone regeneration after implantation. Scaffolds with five different architectures and four porosity levels were fabricated using borate bioactive glass (13–93B3) using the selective laser sintering (SLS) process. The pore size of the scaffolds varied from 400 to 1300 µm. The compressive strength of the scaffolds varied from 1.7 to 15.5 MPa for porosities ranging from 60 to 30%, respectively, for the different architectures. Scaffolds were soaked in a simulated body fluid (SBF) for one week to measure the variation in mechanical properties. The formation of the Hydroxyapatite and in-vitro results are provided and discussed.
In Vitro Assessment of Laser Sintered Bioactive Glass Scaffolds with Different Pore Geometries
(University of Texas at Austin, 2014) Kolan, Krishna C.R.; Thomas, Albin; Leu, Ming C.; Hilmas, Gregory E.
The pore geometry of bioactive glass scaffolds intended for use in bone repair or replacement is one of the most important parameters that could determine the rate of bone regeneration. The pore geometry would also affect the mechanical properties of the scaffolds and their rate of degradation. Scaffolds with five different architectures, having ~50% porosity, were fabricated with silicate (13–93) and borate (13–93B3) based bioactive glasses using a laser sintering process. An established, late-osteoblasts/early-osteocytes cell line was used to perform cell proliferation tests on the scaffolds. The results indicated that the cells proliferate significantly more on the scaffolds which mimic the trabecular bone architecture compared to traditional lattice structures.
Rapid Manufacturing in Biomedical Materials: Using Subtractive Rapid Prototyping for Bone Replacement
(University of Texas at Austin, 2008-09-10) Frank, Matthew C.; Hunt, Christopher V.; Anderson, Donald D.; McKinley, Todd O.; Brown, Thomas D.
This paper presents methods for the rapid manufacturing of replacement bone fragments using a Subtractive Rapid Prototyping process called CNC-RP. The geometry of segmental defects in bone, resulting from traumatic injury or cancerous tumor resection, can be reverse-engineered working from medical images (such as CT scans), and then accurate defect fillers can be automatically generated in advanced synthetic biomaterials and other bioactive/biocompatible materials. The research provides evidence that suitable bone geometries can be created using subtractive RP from a variety of materials including Trabecular Metal® (porous tantalum), polymers, ceramics, and actual bone allografts. The research has implications in the orthopaedic treatment of segmental bone defects, as custom prototyped bone fillers should aid in bone growth and improve recovery.