Browsing by Subject "association"

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Accretion Onto Planetary Mass Companions of Low-Mass Young Stars
(2014-03) Zhou, Yifan; Herczeg, Gregory J.; Kraus, Adam L.; Metchev, Stanimir; Cruz, Kelle L.; Kraus, Adam L.
Measurements of accretion rates onto planetary mass objects may distinguish between different planet Formation mechanisms, which predict different accretion histories. In this Letter, we use Hubble Space Telescope (HST)/WFC3 UVIS optical photometry to measure accretion rates onto three accreting objects, GSC 06214-00210 b, GQ Lup b, and DH Tau b, that are at the planet/brown dwarf boundary and are companions to solar mass stars. The excess optical emission in the excess accretion continuum yields mass accretion rates of 10(-9)-10(-11) M-circle dot yr(-1) for these three objects. Their accretion rates are an order of magnitude higher than expected from the correlation between mass and accretion rates measured from the UV excess, which is applicable if these wide planetary mass companions formed by protostellar core fragmentation. The high accretion rates and large separation from the central star demonstrate the presence of massive disks around these objects. Models for the Formation and evolution of wide planetary mass companions should account for their large accretion rates. High ratios of Ha luminosity over accretion luminosity for objects with low accretion rates suggest that searches for Ha emission may be an efficient way to find accreting planets.
incorporating Health Care Quality into Health Antitrust Law
(2008-04) Schneider, Helen; Schneider, Helen
Antitrust authorities treat price as a proxy for hospital quality since health care quality is difficult to observe. As the ability to measure quality improved, more research became necessary to investigate the relationship between hospital market power and patient outcomes. This paper examines the impact of hospital competition on the quality of care as measured by the risk-adjusted mortality rates with the hospital as the unit of analysis. The study separately examines the effect of competition on non-profit hospitals. Methods: We use California Office of Statewide Health Planning and Development (OSHPD) data from 1997 through 2002. Empirical model is a cross-sectional study of 373 hospitals. Regression analysis is used to estimate the relationship between Coronary Artery Bypass Graft (CABG) risk-adjusted mortality rates and hospital competition. Results: Regression results show lower risk-adjusted mortality rates in the presence of a more competitive environment. This result holds for all alternative hospital market definitions. Nonprofit hospitals do not have better patient outcomes than investor-owned hospitals. However, they tend to provide better quality in less competitive environments. CABG volume did not have a significant effect on patient outcomes. Conclusion: Quality should be incorporated into the antitrust analysis. When mergers lead to higher prices and lower quality, thus lower social welfare, the antitrust challenge of hospital mergers is warranted. The impact of lower hospital competition on quality of care delivered by non-profit hospitals is ambiguous.
Meta-Analysis of Microarray Data Using a Pathway-Based Approach Identifies a 37-Gene Expression Signature for Systemic Lupus Erythematosus in Human Peripheral Blood Mononuclear Cells
(2011-05) Arasappan, Diana; Tong, Weida; Mummaneni, Padmaja; Fang, Hong; Amur, Shashi; Arasappan, Diana
A number of publications have reported the use of microarray technology to identify gene expression signatures to infer mechanisms and pathways associated with systemic lupus erythematosus (SLE) in human peripheral blood mononuclear cells. However, meta-analysis approaches with microarray data have not been well-explored in SLE. Methods: In this study, a pathway-based meta-analysis was applied to four independent gene expression oligonucleotide microarray data sets to identify gene expression signatures for SLE, and these data sets were confirmed by a fifth independent data set. Results: Differentially expressed genes (DEGs) were identified in each data set by comparing expression microarray data from control samples and SLE samples. Using Ingenuity Pathway Analysis software, pathways associated with the DEGs were identified in each of the four data sets. Using the leave one data set out pathway-based meta-analysis approach, a 37-gene metasignature was identified. This SLE metasignature clearly distinguished SLE patients from controls as observed by unsupervised learning methods. The final confirmation of the metasignature was achieved by applying the metasignature to a fifth independent data set. Conclusions: The novel pathway-based meta-analysis approach proved to be a useful technique for grouping disparate microarray data sets. This technique allowed for validated conclusions to be drawn across four different data sets and confirmed by an independent fifth data set. The metasignature and pathways identified by using this approach may serve as a source for identifying therapeutic targets for SLE and may possibly be used for diagnostic and monitoring purposes. Moreover, the meta-analysis approach provides a simple, intuitive solution for combining disparate microarray data sets to identify a strong metasignature. Please see Research Highlight: http://genomemedicine.com/content/3/5/30
A Spitzer c2d Legacy Survey To Identify And Characterize Disks With Inner Dust Holes
(2010-08) Merin, Bruno; Brown, Joanna M.; Oliveira, Isa; Herczeg, Gregory J.; van Dishoeck, Ewine F.; Bottinelli, Sandrine; Evans, Neal J.; Cieza, Lucas; Spezzi, Loredana; Alcala, Juan M.; Harvey, Paul M.; Blake, Geoffrey A.; Bayo, Amelia; Geers, Vincent G.; Lahuis, Fred; Prusti, Timo; Augereau, Jean-Charles; Olofsson, Johan; Walter, Frederick M.; Chiu, Kuenley; Evans, Neal J.; Harvey, Paul M.
Understanding how disks dissipate is essential to studies of planet formation. However, identifying exactly how dust and gas dissipate is complicated due to the difficulty of finding objects that are clearly in the transition phase of losing their surrounding material. We use Spitzer Infrared Spectrograph (IRS) spectra to examine 35 photometrically selected candidate cold disks (disks with large inner dust holes). The infrared spectra are supplemented with optical spectra to determine stellar and accretion properties and 1.3 mm photometry to measure disk masses. Based on detailed spectral energy distribution modeling, we identify 15 new cold disks. The remaining 20 objects have IRS spectra that are consistent with disks without holes, disks that are observed close to edge-on, or stars with background emission. Based on these results, we determine reliable criteria to identify disks with inner holes from Spitzer photometry, and examine criteria already in the literature. Applying these criteria to the c2d surveyed star-forming regions gives a frequency of such objects of at least 4% and most likely of order 12% of the young stellar object population identified by Spitzer. We also examine the properties of these new cold disks in combination with cold disks from the literature. Hole sizes in this sample are generally smaller than in previously discovered disks and reflect a distribution in better agreement with exoplanet orbit radii. We find correlations between hole size and both disk and stellar masses. Silicate features, including crystalline features, are present in the overwhelming majority of the sample, although the 10 mu m feature strength above the continuum declines for holes with radii larger than similar to 7 AU. In contrast, polycyclic aromatic hydrocarbons are only detected in 2 out of 15 sources. Only a quarter of the cold disk sample shows no signs of accretion, making it unlikely that photoevaporation is the dominant hole-forming process in most cases.