Browsing by Subject "Visual appearance"

Now showing 1 - 1 of 1

Among the coformers and cocrystals
(2023-12) Wilson, Ilham Zaky; Maniruzzaman, Mohammed; Cui, Zhengrong
Cocrystals have emerged as an exciting avenue for altering the behavior of drugs and creating new patents or intellectual properties in the pharmaceutical industry. However, the preparation of pharmaceutical cocrystals remains relatively uncommon, presenting a potential field for innovation. The advantage of cocrystals lies in their ability to preserve the molecular structures of the active pharmaceutical ingredients, thereby avoiding the need for complicated approval paperwork and clinical trials associated with new drug entities. In this study, our focus is on the development of cocrystals for Fleroxacin, a fluoroquinolone antibiotic belonging to the quinolone antibiotic class. Fleroxacin exhibits versatility in treating various bacterial infections. Our approach involves cocrystallizing Fleroxacin with a few small molecule APIs and nutrients, namely nicotinamide, salicylamide, and acetaminophen. This combination of Fleroxacin with different coformers allows us to explore the potential for enhancing its chemical properties and therapeutic efficacy. To achieve cocrystal formation, we employed a novel catalyst, pure glacfial acetic acid, in conjunction with a ball milling machine. This methodology is particularly notable as it represents a first-time application of pure glacial acetic acid for cocrystallization and the cocrystallization of Fleroxacin. Also, prior to the synthesis, we ensured the absence of any undesirable reactions between the reactants and glacial acetic acid, thereby ensuring the integrity of the cocrystals formed (eliminating the possibilities of solvate and salt formations). Sample analysis and identification were done with physical examinations (e.g., visual appearance) and high-resolution synchrotron X-ray diffraction analysis at Argonne National Laboratory in addition to standard laboratory X-ray diffraction at The University of Texas Department of Chemistry and Texas Material Institute. The findings of this study contribute to the expanding body of knowledge on cocrystallization techniques and their potential applications in pharmaceutical development. Moreover, the successful synthesis and characterization of these Fleroxacin cocrystals with salicylamide, nicotinamide, and acetaminophen open up possibilities for further investigations into their chemical properties and potential therapeutic benefits.