Browsing by Subject "Macroscopic fluorescence imaging system"
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Item Investigation of the invasive phenotype of inflammatory breast cancer(2005-05-21) Hoffmeyer, Michaela Ross; Dharmawardhane, Surangani F.; Richards-Kortum, Rebecca, 1964-Inflammatory breast cancer (IBC) is a highly aggressive form of breast cancer characterized by a dermal inflammatory-like presentation. This phenotype maybe due to a unique method of invasion that is not well characterized. This thesis presents an in vitro analysis of the SUM 149 (IBC) and the SUM 102 (non-IBC) cell lines. This analysis revealed a reduced invasive and adhesive capacity to basal lamina components by the IBC cell line, possibly suggesting a passive mode of IBC dissemination. Cell lines that stably expressing red fluorescent protein (RFP), RFP-IBC and RFP-MDA-MB- 435[alpha]6HG6 breast cancer cell lines, were constructed and used successfully to optimize a macroscopic fluorescence imaging system to determine tumor take, monitoring tumor growth, and locating sites of metastasis. Moreover, this system can be adapted for in situ, non-invasive assessment of breast cancer chemotherapeutics and preventatives