Browsing by Subject "Fiber"

Now showing 1 - 2 of 2
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    Cytoplasmic foci at the crossroads of artifactual science and biological function
    (2016-05) Zhao, Alice; Marcotte, Edward M.; Ellington, Andrew D; Zhang, Yan J; Appling, Dean R; Iyer, Vishwanath R
    Deciphering protein interaction and compartmentalization is crucial to understanding the molecular mechanisms that drive biological processes. Using various high throughput approaches, we have managed to score subcellular dynamic protein re-organization into supramolecular structures and map physical association networks to discover protein complexes on a proteome-wide level. However, the case by case studies of some of these novel structures and interactions reveal difficulties in interpreting their biological basis. This study offers insights into limits inherent in the molecular techniques used to investigate subcellular structures and protein interactions, describing a set of cautionary tales and critical analysis for deciphering cases of confounding data from orthogonal approaches. This study also offers a new experimental technique for high-throughput imaging assays with mammalian cell lines.
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    Seismic retrofit of RC columns with FRP composites and anchorage system
    (2015-05) Psaros Andriopoulos, Apostolos; Jirsa, J. O. (James Otis); Hrynyk, Trevor
    Research on the use of composite materials in structural applications started more than 30 years ago but still remains active. The challenges that accompany those applications are diverse and seem to increase as the variety of applications grows. There are several fiber-reinforced polymer (FRP) systems that have been introduced through the years for strengthening reinforced concrete (RC) structures. Those systems focus on strengthening of slabs, beams and columns. The present study pertains to seismic retrofit of rectangular RC columns. The typical FRP materials used in structural applications are introduced, as well as, how FRP materials become an integral part of the force-resisting system. In addition, analysis work pertaining to a series of strengthened RC columns was conducted and the results were compared to the experimental data. Moreover, deficiencies of typical material models were highlighted. Design guidelines are discussed and recommendations about current design practices are provided. Finally, research gaps and future research recommendations are identified.