Browsing by Department "Board of Regents, University of Texas System"

Now showing 1 - 20 of 1194

1,2-diaminocyclohexane-platinum complexes with antitumor activity
(United States Patent and Trademark Office, 1991-04-30) Khokhar, Abdul R.; Newman, Robert A. III; Krakoff, Irwin H.; Board of Regents, Univ. of Tex. Sys.
The present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula: EQU trans-R,R-DACH Pt(II) X.sub.2 or EQU trans-R,R-DACH Pt(II) Y wherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH. In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula: EQU trans-R,R-DACH Pt(II) X.sub.2 wherein X is a monovalent cation. Two X substituents are present in the platinum complex. These X substituents are preferably selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethylglycinato. Both X substituents are usually identical butmay be different.
19F labelled dextrans and antibodies as NMR imaging and spectroscopy agents
(United States Patent and Trademark Office, 1993-08-17) Kulkarni, Padmakar V.; Antich, Peter P.; Board of Regents, Univ. of Tex. Sys.
.sup.19 F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a .sup.19 F-containing sensor moiety, and a transport polymer or substrate, and can optionally also comprise a spacer moiety to separate the sensor moiety and the transport polymer.
Abating low-frequency noise using encapsulated gas bubbles
(United States Patent and Trademark Office, 2014-04-08) Preston S. Wilson; Kevin M. Lee; Mark S. Wochner; The Board of Regents of the University of Texas System
Air bubbles may be used to reduce radiated underwater noise. Two modalities of sound attenuation by air bubbles were shown to provide a reduction in radiated sound: bubble acoustic resonance damping and acoustic impedance mismatching. The bubbles used for acoustic resonance damping were manifested using gas-filled containers coupled to a support, and the acoustic impedance mismatching bubbles were created using a cloud of freely-rising bubbles, which were both used to surround an underwater sound source.
Accurately tracking a mobile device to effectively enable mobile device to control another device
(United States Patent and Trademark Office, 2019-01-15) Wenguang Mao; Lili Qiu; Board of Regents, The University of Texas System
A method, system and computer program product for tracking a mobile device. A reference position of the mobile device and a frequency offset between the mobile device and another device are estimated. Samples are then fetched at various frequencies from the receivers. The fetched signals are mixed with a pseudo transmitted signal. A relative distance between the mobile device and the other device is computed based on a change in frequency of the mixed signal at a current location, a velocity of the mobile device and the estimated frequency offset. An absolute distance between the mobile device and the other device is determined using the reference position and the computed relative distance. A location of the mobile device is then determined based on the mobile device's velocity and the determined absolute difference.
Acetic acid as a contrast in reflectance confocal imaging of tissue
(United States Patent and Trademark Office, 2001-02-13) Rebecca R. Richards-Kortum; Rebekah Drezek; Colin L. Smithpeter; Andres Zuluaga; Board of Regents, The University of Texas System
A method for using acetic acid as a contrast agent during reflectance confocal imaging of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of using acetic acid as a contrast agent for confocal imaging of cells, including applying acetic acid to the diagnostic tissue sample in sufficient concentration to induce a small scale alteration of the index of refraction of nuclei in the cells; and imaging such cells using a reflectance confocal imaging system.
Acidic gas capture by diamines
(United States Patent and Trademark Office, 2011-05-10) Gary T. Rochelle; Marcus Hilliard; Board of Regents, The University of Texas System
Compositions and methods related to the removal of acidic gas. In particular, the present disclosure relates to a composition and method for the removal of acidic gas from a gas mixture using a solvent comprising a diamine (e.g., piperazine) and carbon dioxide. One example of a method may involve a method for removing acidic gas comprising contacting a gas mixture having an acidic gas with a solvent, wherein the solvent comprises piperazine in an amount of from about 4 to about 20 moles/kg of water, and carbon dioxide in an amount of from about 0.3 to about 0.9 moles per mole of piperazine.
Acidic gas removal by aqueous amine solvents
(United States Patent and Trademark Office, 2014-08-26) Gary T. Rochelle; Xi Chen; Stephanie A. Freeman; Thu Nguyen; Alexander Voice; Humera A. Rafique; Board of Regents, The University of Texas System
Compositions and methods related to the removal of acidic gas. In one embodiment, compositions and methods are provided for the removal of acidic gas from a gas mixture using an aqueous amine solvent comprising water, a first amine, and a second amine, wherein the first amine contributes at least 50% by weight of the solvent's total amine concentration.
Acoustic sensor
(United States Patent and Trademark Office, 2016-06-21) Neal A. Hall; Michael Louis Kuntzman; Donghwan Kim; Nishshanka Hewa-Kasakarage; Board of Regents, The University of Texas System
A method of designing and manufacturing an acoustic sensor having a high degree of directivity is disclosed. The sensor includes a rotatable plate that is attached to a substrate with mounts. In one aspect the mounts are freely rotatable and the torque on the plate is measured using detectors disposed on springs that provide a resistance to rotation of the plate. In another aspect the plate is mounted to the substrate with mounts that torsionally deform during rotation of the plate. These detectors measure the torque on the plate according to the torsional deformation of the mounts. Methods of improving the signal to noise ratio of acoustic sensors having multiple detectors are also disclosed.
Acoustical stimulation of vapor diffusion system and method
(United States Patent and Trademark Office, 2007-07-03) Meegan, Jr., G. Douglas; Board of Regents, The University of Texas System
An apparatus for removing constituents from a fluid stream is provided. The apparatus includes a duct, a collection device, a sorbent injector, and an acoustic generator. The duct has a fluid passageway to receive a fluid stream having constituents. The collection device filters the fluid stream. The sorbent injector injects a sorbent in the fluid passageway of the duct. The acoustic generator generates an acoustic field in the fluid passageway of the duct to promote sorption of the constituents for collection by the collection device. Additionally, a method is provided for removing constituents from a fluid stream.
Active-electrode integrated biosensor array and methods for use thereof
(United States Patent and Trademark Office, 2016-05-17) Arjang Hassibi; Arun Manickam; Rituraj Singh; Board of Regents, The University of Texas System
A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.
Active-electrode integrated biosensor array and methods for use thereof
(United States Patent and Trademark Office, 2016-10-11) Arjang Hassibi; Arun Manickam; Rituraj Singh; Board of Regents, The University of Texas System
A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.
Adaptive feedback method for cellular communication
(United States Patent and Trademark Office, 2010-04-06) Sung Hyun Cho; Robert W. Heath, Jr.; Sang-Boh Yun; Taiwen Tang; Board of Regents, The University of Texas System; Samsung Electronics Co., Ltd.
In an adaptive feedback method for a cellular communication system having plural terminals feeding back channel information to an access point, the system selects one of an opportunistic mode and a polling mode as a feedback mode between an access point and the terminals on the basis of system and traffic parameters, sets up the access point and the terminals for the selected feedback mode, and feeds back the channel information from the terminals to the access point in the selected feedback mode. The adaptive feedback method changes the feedback mechanism adaptively to the system and traffic environment, making it possible to increase the system throughput as well as to decrease the MAC overhead regardless of the variation of the number of MSs.
Adaptive nanotopography sculpting
(United States Patent and Trademark Office, 2013-03-12) Sidlgata V. Sreenivasan; Avinash Panga; Board of Regents, The University of Texas System
Adaptive imprint planarization provides a surface having desired shape characteristics. Generally, topography of a first surface is mapped to provide a density map. The density map is evaluated to provide a drop pattern for dispensing polymerizable material on the first surface. The polymerizable material is solidified and etched to provide a second surface having the desired shape characteristics. Additionally, adaptive imprint planarization compensates for parasitic effects of the imprinting process.
Adaptive shape substrate support method
(United States Patent and Trademark Office, 2009-03-17) Mahadevan GanapathiSubramanian; Sldlgata V. Sreenivasan; Board of Regents, The University of Texas System
The present method features an active compliant pin chuck to hold a substrate, having opposed first and second surfaces, and compensates for non-planarity in one of the surfaces of the substrate. To that end, the method includes creating a point contact on the first surface to generate a change in shape of the second surface to obtain a desired shape of the second surface. The desired shape may be smooth, if not substantially planar or any other shape desired within the operational parameters of the chuck and the substrate. For example, the method may compensate for non-planarity due to particulate matter on the first surface and substrate topography. These and other embodiments are discussed more fully below.
Adaptive shape substrate support system
(United States Patent and Trademark Office, 2007-12-11) Sidlgata V. Sreenivasan; Mahadevan GanapathiSubramanian; Board of Regents, The University of Texas System
The present method and system features an active compliant pin chuck to hold a substrate, having opposed first and second surfaces, and compensates for non-planarity in one of the surfaces of the substrate. To that end, the support system includes a chuck having a plurality of piezo pins and reference pins, with the piezo pins being coupled to piezo actuators to undergo relative movement with respect to said reference pins. These and other embodiments are discussed more fully below.
Administration of kynurenine depleting enzymes for tumor therapy
(United States Patent and Trademark Office, 2018-05-22) George M. Georgiou; Everett Stone; Wei-Cheng Lu; John Blazeck; Nicholas Marshall; Board of Regents, The University of Texas System
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
Administration of kynurenine depleting enzymes for tumor therapy
(United States Patent and Trademark Office, 2017-11-07) George M. Georgiou; Everett Stone; Board of Regents, The University of Texas System
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
Admittance measurement for tuning bi-ventricular pacemakers
(United States Patent and Trademark Office, 2018-09-18) Marc D. Feldman; Jonathan W. Valvano; John A. Pearce; John R. Porterfield; Erik Steven Larson; Admittance Technologies, Inc.; Board of Regents, The University of Texas System
An apparatus for treating a heart of a patient includes a first lead and at least a second lead for pacing the heart adapted to be in electrical communication with the heart. The apparatus includes a microcontroller in communication with the first and second leads which triggers the first lead at either different times or the same time from when the microcontroller triggers the second lead. Alternatively, the apparatus includes a microcontroller in communication with the first and second leads that determines heart volume, including stroke volume, end-systolic volume, and calculated values including ejection fraction, from admittance from signals from the first and second leads and uses the admittance as feedback to control heart volume ejected, as measured by stroke volume, calculated values such as ejection fraction, and control end-systolic volume, with respect to the first and second leads. A method for treating the heart of a patient.
Aerosol jet etching
(United States Patent and Trademark Office, 1991-08-20) James R. Brock; Isaac Trachtenberg; Board of Regents, The University of Texas System
A device and method for etching a body are provided capable of etching fine geometry patterns utilizing the high selectivity of wet etching and the anisotropic etch characteristics of dry etching. The body to be etched is placed in a reduced pressure etching chamber. An inert carrier gas is bubbled through heated liquid etchant producing a vapor stream of liquid etchant. A non-reactive gas is chilled producing a cold gas stream. The vapor stream and the cold gas stream are combined in an aerosol generation nozzle producing a high concentration of fine aerosol particles by homogeneous nucleation. The fine aerosol particles enter an aerosol growth chamber and form larger particles through thermal coagulation. The larger particles are accelerated out of the growth chamber through an expansion nozzle positioned within the reduced pressure etching chamber and directed toward the body to be etched. This aerosol jet of etchant impacts the surface of the body to be etched. The small size of these larger particles allows for etching fine geometry patterns. Additionally, aerosol jet etching avoids the need to rinse the body after being etched as required in wet etching to halt the etching process.
Aerosol-mediated particle synthesis
(United States Patent and Trademark Office, 2014-02-18) Hugh D. Smyth; Ibrahim M. El-Sherbiny; Board of Regents, The University of Texas System
Disclosed are aerosol-mediated methods for synthesizing particles for biomedical and drug delivery applications. The method is based on the production of particles from sprayed polymeric micro or nano-droplets obtained by, for example, an air-jet nebulization process that is followed by gelation and/or hardening in a crosslinking fluid, non-solvent, precipitating solvent, or supercritical fluid.