The global COVID-19 pandemic has dramatically affected daily life, most especially among healthcare workers and providers (HCWPs). Characterized by a seemingly endless number of new COVID-19 cases and a high death toll, the ongoing pandemic has negatively affected HCWPs in the workplace and at home, especially those serving socially disadvantaged populations. In this brief, the Latino Research Institute outlines recommendations for organizations to protect the mental health and well-being of HCWPs who are exposed to extreme circumstances.