Multi-material nanoindentation simulations of viral capsids

Repository

Multi-material nanoindentation simulations of viral capsids

Show full record

Title: Multi-material nanoindentation simulations of viral capsids
Author: Subramanian, Bharadwaj
Abstract: An understanding of the mechanical properties of viral capsids (protein assemblies forming shell containers) has become necessary as their perceived use as nano-materials for targeted drug delivery. In this thesis, a heterogeneous, spatially detailed model of the viral capsid is considered. This model takes into account the increased degrees of freedom between the capsomers (capsid sub-structures) and the interactions between them to better reflect their deformation properties. A spatially realistic finite element multi-domain decomposition of viral capsid shells is also generated from atomistic PDB (Protein Data Bank) information, and non-linear continuum elastic simulations are performed. These results are compared to homogeneous shell simulation re- sults to bring out the importance of non-homogenous material properties in determining the deformation of the capsid. Finally, multiscale methods in structural analysis are reviewed to study their potential application to the study of nanoindentation of viral capsids.
Department: Computational Science, Engineering, and Mathematics Program
Subject: Nanoindentation Multiscale methods Multimaterial meshing Viral capsids CCMV Biomedical engineering Hyperelasticity Inverse problems Coarse graining
URI: http://hdl.handle.net/2152/ETD-UT-2010-05-1462
Date: 2010-05

Files in this work

Download File: SUBRAMANIAN-THESIS.pdf
Size: 12.85Mb
Format: application/pdf

This work appears in the following Collection(s)

Show full record


Advanced Search

Browse

My Account

Statistics

Information